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KMID : 1188320180120030271
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Gut and Liver
2018 Volume.12 No. 3 p.271 ~ p.277
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Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study
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Kim Joon-Sung
Kim Byung-Wook
Park Sung-Min
Shim Ki-Nam
Jeon Seong-Woo
Kim Sang-Wook
Lee Yong-Chan
Moon Hee-Seok
Lee Si-Hyung
Jung Woon-Tae
Kim Jin-Il
Kim Kyoung-Oh
Park Jong-Jae
Chung Woo-Chul
Kim Jeong-Hwan
Baik Gwang-Ho
Oh Jung-Hwan
Kim Sun-Moon
Kim Hyun-Soo
Yang Chang-Heon
Jung Jin-Tae
Lim Chul-Hyun
Song Hyun-Joo
Kim Yong-Sik
Kim Gwang-Ha
Kim Jie-Hyun
Chung Jae-Il
Lee Jun-Haeng
Choi Min-Ho
Choi Jong-Kyoung
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Abstract
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Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB.
Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding.
Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations.
Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.
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KEYWORD
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Peptic ulcer hemorrhage, Rebleeding, Risk factors
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